{"id":28819,"date":"2026-10-26T10:30:00","date_gmt":"2026-10-26T17:30:00","guid":{"rendered":"https:\/\/getheally.com\/patients\/news\/semaglutide-dosing-guidelines-copy"},"modified":"2026-10-27T07:51:50","modified_gmt":"2026-10-27T14:51:50","slug":"semaglutide-vs-other-glp-1","status":"publish","type":"post","link":"https:\/\/getheally.com\/patients\/news\/semaglutide-vs-other-glp-1","title":{"rendered":"Semaglutide vs other GLP-1 medications: how every option compares in 2026"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Semaglutide is one of the most effective GLP-1 medications for weight loss and type 2 diabetes. It&#8217;s also the one with the most FDA-approved uses. It beats older GLP-1s like liraglutide and dulaglutide for weight loss by a wide margin. In a head-to-head trial, people lost 15.8% of their body weight on semaglutide vs 6.4% on liraglutide. Tirzepatide, a dual GLP-1 and GIP drug, leads to more weight loss than semaglutide, and newer pills and triple-action drugs are arriving. Still, semaglutide stands out for its pill and injection options, proven heart and kidney benefits and affordable self-pay prices. Here&#8217;s how semaglutide compares with every GLP-1 option available in 2026.<\/span><\/p>\n<h2 id=\"key-takeaways\"><span style=\"font-weight: 400;\">Key takeaways<\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Semaglutide is sold as Wegovy (injection and pill) for weight loss, and as Ozempic and Rybelsus for type 2 diabetes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Semaglutide leads to more weight loss than liraglutide (Saxenda) and dulaglutide (Trulicity), the older GLP-1 medications<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tirzepatide (Zepbound, Mounjaro) leads to more weight loss than semaglutide: 20.2% vs 13.7% in the SURMOUNT-5 trial<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Semaglutide has proven benefits for the heart, kidneys and liver, and it&#8217;s the only GLP-1 with both weekly injection and daily pill options for weight loss<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Exenatide (Byetta, Bydureon BCise) and lixisenatide (Adlyxin) have been discontinued in the US<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Foundayo is a newer daily GLP-1 pill, and retatrutide is an investigational drug that isn&#8217;t approved yet<\/span><\/li>\n<\/ul>\n<h2 id=\"what-are-glp-1-receptor-agonists\"><span style=\"font-weight: 400;\">What are GLP-1 receptor agonists?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">GLP-1 (glucagon-like peptide-1) is a hormone your gut releases after you eat. GLP-1 receptor agonists are medications that mimic it. They work in four main ways:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Reduce appetite<\/b><span style=\"font-weight: 400;\"> by signaling fullness to the brain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Slow stomach emptying,<\/b><span style=\"font-weight: 400;\"> so you feel full longer<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Boost insulin release<\/b><span style=\"font-weight: 400;\"> when blood sugar is high<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Lower glucagon,<\/b><span style=\"font-weight: 400;\"> a hormone that raises blood sugar<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">GLP-1 medications were first developed for type 2 diabetes. Researchers then found that higher doses lead to significant weight loss. Today, several are FDA approved for weight management.<\/span><\/p>\n<h2 id=\"the-glp-1-medications-list-for-2026\"><span style=\"font-weight: 400;\">The GLP-1 medications list for 2026<\/span><\/h2>\n<table>\n<thead>\n<tr>\n<th><b>Active ingredient<\/b><\/th>\n<th><b>Brand names<\/b><\/th>\n<th><b>Dosing<\/b><\/th>\n<th><b>FDA-approved for weight loss?<\/b><\/th>\n<th><b>Status<\/b><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Semaglutide<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Wegovy, Ozempic, Rybelsus<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Weekly injection or daily pill<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (Wegovy)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Available<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Tirzepatide (GLP-1 and GIP)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Zepbound, Mounjaro<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Weekly injection<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (Zepbound)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Available<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Liraglutide<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Saxenda, Victoza, generics<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Daily injection<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (Saxenda)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Available<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Dulaglutide<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Trulicity<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Weekly injection<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Available, for type 2 diabetes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Orforglipron<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Foundayo<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Daily pill<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Available since April 2026<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Exenatide<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Byetta, Bydureon BCise<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Twice daily or weekly injection<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Discontinued in the US<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Lixisenatide<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Adlyxin<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Daily injection<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Discontinued in the US<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Retatrutide (GLP-1, GIP and glucagon)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">None yet<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Weekly injection<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Investigational, in phase 3 trials<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"semaglutide-the-benchmark-glp-1\"><span style=\"font-weight: 400;\">Semaglutide: the benchmark GLP-1<\/span><\/h2>\n<p><a href=\"https:\/\/getheally.com\/patients\/semaglutide\"><span style=\"font-weight: 400;\">Semaglutide<\/span><\/a><span style=\"font-weight: 400;\"> is a once-weekly GLP-1 injection, and it&#8217;s also available as a daily pill. It comes in four brands:<\/span><\/p>\n<table>\n<thead>\n<tr>\n<th><b>Brand<\/b><\/th>\n<th><b>Form<\/b><\/th>\n<th><b>Approved for<\/b><\/th>\n<th><b>Approved since<\/b><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><a href=\"https:\/\/getheally.com\/patients\/wegovy\"><span style=\"font-weight: 400;\">Wegovy<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Weekly injection, up to 2.4 mg (7.2 mg as Wegovy HD)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Weight management, heart risk reduction, MASH<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2021<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/getheally.com\/patients\/wegovy-pills\"><span style=\"font-weight: 400;\">Wegovy pill<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Daily tablet, up to 25 mg<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Weight management, heart risk reduction<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2025<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/getheally.com\/patients\/ozempic\"><span style=\"font-weight: 400;\">Ozempic<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Weekly injection, up to 2 mg<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Type 2 diabetes, heart and kidney risk reduction<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2017<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/getheally.com\/patients\/rybelsus\"><span style=\"font-weight: 400;\">Rybelsus<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Daily tablet<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Type 2 diabetes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2019<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><b>Weight loss results:<\/b><span style=\"font-weight: 400;\"> In the STEP 1 trial, people on Wegovy 2.4 mg lost 14.9% of their body weight over 68 weeks. In the STEP UP trial, Wegovy HD (7.2 mg) led to about 19% to 21% weight loss. The 25 mg Wegovy pill led to about 14% to 17% weight loss over 64 weeks in OASIS 4.<\/span><\/p>\n<p><b>Beyond weight loss:<\/b><span style=\"font-weight: 400;\"> Semaglutide has proven heart benefits. In the SELECT trial, Wegovy lowered the risk of heart attack, stroke and heart-related death by 20%. It also protects the kidneys in people with type 2 diabetes and chronic kidney disease, and it&#8217;s approved for MASH liver disease with fibrosis.<\/span><\/p>\n<h2 id=\"semaglutide-vs-liraglutide-saxenda-victoza\"><span style=\"font-weight: 400;\">Semaglutide vs liraglutide (Saxenda, Victoza)<\/span><\/h2>\n<p><a href=\"https:\/\/getheally.com\/patients\/liraglutide\"><span style=\"font-weight: 400;\">Liraglutide<\/span><\/a><span style=\"font-weight: 400;\"> is an older GLP-1 taken as a daily injection. Saxenda is approved for weight loss, and Victoza is approved for type 2 diabetes.<\/span><\/p>\n<table>\n<thead>\n<tr>\n<th><b>Feature<\/b><\/th>\n<th><b>Semaglutide (Wegovy)<\/b><\/th>\n<th><b>Liraglutide (Saxenda)<\/b><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Dosing<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Once weekly<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Once daily<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Average weight loss, STEP 8 head-to-head (68 weeks)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">15.8%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">6.4%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Stopped due to side effects in STEP 8<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3.2%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">12.6%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Generic available<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes, since 2024 to 2025<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span style=\"font-weight: 400;\">Semaglutide clearly wins on weight loss and convenience. Liraglutide&#8217;s advantages are that generic versions are available, it clears from the body quickly and Saxenda is approved for teens aged 12 and up. For what to expect on liraglutide, see <\/span><a href=\"https:\/\/getheally.com\/patients\/news\/how-long-does-liraglutide-take-to-work-and-when-to-expect-results\"><span style=\"font-weight: 400;\">how long liraglutide takes to work<\/span><\/a><span style=\"font-weight: 400;\">. Thinking of combining or switching them? Read <\/span><a href=\"https:\/\/getheally.com\/patients\/news\/can-you-take-semaglutide-and-liraglutide-together-safely\"><span style=\"font-weight: 400;\">can you take semaglutide and liraglutide together<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h2 id=\"semaglutide-vs-dulaglutide-trulicity\"><span style=\"font-weight: 400;\">Semaglutide vs dulaglutide (Trulicity)<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Dulaglutide (Trulicity) is a weekly GLP-1 injection approved for type 2 diabetes, but not for weight loss.<\/span><\/p>\n<table>\n<thead>\n<tr>\n<th><b>Feature<\/b><\/th>\n<th><b>Semaglutide (Ozempic 1 mg)<\/b><\/th>\n<th><b>Dulaglutide (Trulicity 1.5 mg)<\/b><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">HbA1c reduction, SUSTAIN 7 head-to-head (40 weeks)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">-1.8%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">-1.4%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Weight loss, SUSTAIN 7<\/span><\/td>\n<td><span style=\"font-weight: 400;\">About 6.5 kg<\/span><\/td>\n<td><span style=\"font-weight: 400;\">About 3.0 kg<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Heart benefits<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Proven (SUSTAIN-6, SELECT)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Proven (REWIND)<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Approved for weight loss<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes, as Wegovy<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span style=\"font-weight: 400;\">Semaglutide lowers blood sugar and weight more than dulaglutide. Dulaglutide remains a solid diabetes option, with an easy-to-use pen and proven heart benefits.<\/span><\/p>\n<h2 id=\"semaglutide-vs-tirzepatide-zepbound-mounjaro\"><span style=\"font-weight: 400;\">Semaglutide vs tirzepatide (Zepbound, Mounjaro)<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Tirzepatide acts on two hormone receptors, GLP-1 and GIP, so it&#8217;s not a pure GLP-1 drug. It&#8217;s sold as <\/span><a href=\"https:\/\/getheally.com\/patients\/zepbound\"><span style=\"font-weight: 400;\">Zepbound<\/span><\/a><span style=\"font-weight: 400;\"> for weight loss and sleep apnea, and as <\/span><a href=\"https:\/\/getheally.com\/patients\/mounjaro\"><span style=\"font-weight: 400;\">Mounjaro<\/span><\/a><span style=\"font-weight: 400;\"> for type 2 diabetes.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Weight loss:<\/b><span style=\"font-weight: 400;\"> In the SURMOUNT-5 head-to-head trial, tirzepatide led to 20.2% weight loss vs 13.7% with semaglutide over 72 weeks<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Side effects:<\/b><span style=\"font-weight: 400;\"> Similar for both, mainly digestive<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Approvals:<\/b><span style=\"font-weight: 400;\"> Semaglutide has more, including MASH and a pill form. Tirzepatide is approved for sleep apnea and, since 2026, heart risk reduction in type 2 diabetes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Cost:<\/b><span style=\"font-weight: 400;\"> Self-pay prices are similar, about $299 to $449 a month for Zepbound vs $349 for Wegovy pens<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">We cover this comparison in depth in <\/span><a href=\"https:\/\/getheally.com\/patients\/news\/tirzepatide-vs-semaglutide\"><span style=\"font-weight: 400;\">tirzepatide vs semaglutide: what&#8217;s the difference<\/span><\/a><span style=\"font-weight: 400;\"> and the dose-by-dose guide <\/span><a href=\"https:\/\/getheally.com\/patients\/news\/tirzepatide-vs-semaglutide-dosage-for-weight-loss\"><span style=\"font-weight: 400;\">tirzepatide vs semaglutide dosage<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Weight loss care at Heally: <\/span><a href=\"https:\/\/getheally.com\/patients\/weight-loss-prescription\"><span style=\"font-weight: 400;\">weight loss prescription<\/span><\/a><span style=\"font-weight: 400;\"> \u00b7 <\/span><a href=\"https:\/\/getheally.com\/patients\/test-for-weight-loss\"><span style=\"font-weight: 400;\">weight loss lab panel<\/span><\/a><span style=\"font-weight: 400;\"> \u00b7 <\/span><a href=\"https:\/\/getheally.com\/patients\/doctors\"><span style=\"font-weight: 400;\">meet our doctors<\/span><\/a><\/p>\n<h2 id=\"oral-semaglutide-vs-foundayo-orforglipron\"><span style=\"font-weight: 400;\">Oral semaglutide vs Foundayo (orforglipron)<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Two daily GLP-1 pills are now approved for weight loss:<\/span><\/p>\n<table>\n<thead>\n<tr>\n<th><b>Feature<\/b><\/th>\n<th><b>Wegovy pill (oral semaglutide)<\/b><\/th>\n<th><a href=\"https:\/\/getheally.com\/patients\/foundayo\"><b>Foundayo<\/b><\/a><b> (orforglipron)<\/b><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Type of drug<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Peptide GLP-1<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Small-molecule (non-peptide) GLP-1<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">How to take it<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Empty stomach, a little water, wait 30 minutes to eat<\/span><\/td>\n<td><span style=\"font-weight: 400;\">With or without food and water<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Average weight loss in main trial<\/span><\/td>\n<td><span style=\"font-weight: 400;\">About 14% to 17% (64 weeks)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">About 11% to 12% (72 weeks)<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Self-pay starting price<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$149 a month<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$149 a month<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span style=\"font-weight: 400;\">The Wegovy pill led to more weight loss in its trial, while Foundayo is easier to take. Compare pills and shots in <\/span><a href=\"https:\/\/getheally.com\/patients\/news\/wegovy-pills-vs-injection-a-complete-comparison-guide-for-2026\"><span style=\"font-weight: 400;\">Wegovy pills vs injection<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h2 id=\"discontinued-glp-1-medications-exenatide-and-lixisenatide\"><span style=\"font-weight: 400;\">Discontinued GLP-1 medications: exenatide and lixisenatide<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Two older GLP-1 drugs are no longer sold in the US:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Exenatide (Byetta and Bydureon BCise).<\/b><span style=\"font-weight: 400;\"> Byetta was the first GLP-1 approved in 2005. Both were discontinued in the US in 2024<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Lixisenatide (Adlyxin).<\/b><span style=\"font-weight: 400;\"> A daily injection for type 2 diabetes, discontinued in the US in 2023<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If you took one of these, your provider can help you switch to a current option such as semaglutide, dulaglutide or tirzepatide.<\/span><\/p>\n<h2 id=\"coming-soon-retatrutide\"><span style=\"font-weight: 400;\">Coming soon: retatrutide<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Retatrutide is an investigational once-weekly injection that acts on three hormone receptors: GLP-1, GIP and glucagon. In the phase 3 TRIUMPH-1 trial, people on the highest dose lost an average of 28.3% of their body weight over 80 weeks. That&#8217;s more than any approved weight loss drug so far. It isn&#8217;t FDA approved, and any product sold as retatrutide today isn&#8217;t a legal or tested medication.<\/span><\/p>\n<h2 id=\"semaglutide-vs-other-glp-1s-side-effects\"><span style=\"font-weight: 400;\">Semaglutide vs other GLP-1s: side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">All GLP-1 medications share a similar side effect profile:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea, the most common, usually during dose increases<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea, constipation and vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reduced appetite and early fullness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Injection site reactions, for injected forms<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Side effects differ more by dose and how fast the dose is increased than by drug. In STEP 8, fewer people stopped semaglutide because of side effects than liraglutide. For semaglutide vs tirzepatide specifically, see <\/span><a href=\"https:\/\/getheally.com\/patients\/news\/what-medication-has-fewer-side-effects-semaglutide-or-tirzepatide-2\"><span style=\"font-weight: 400;\">which has fewer side effects<\/span><\/a><span style=\"font-weight: 400;\">. For why nausea happens and how to ease it, read <\/span><a href=\"https:\/\/getheally.com\/patients\/news\/why-do-glp-1-medications-cause-nausea\"><span style=\"font-weight: 400;\">why GLP-1 medications cause nausea<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">All of these medications carry warnings about pancreatitis and gallbladder problems. Semaglutide, tirzepatide, liraglutide and dulaglutide also carry a boxed warning about thyroid C-cell tumors.<\/span><\/p>\n<h2 id=\"semaglutide-vs-other-glp-1s-benefits-beyond-weight-loss\"><span style=\"font-weight: 400;\">Semaglutide vs other GLP-1s: benefits beyond weight loss<\/span><\/h2>\n<table>\n<thead>\n<tr>\n<th><b>Benefit<\/b><\/th>\n<th><b>Semaglutide<\/b><\/th>\n<th><b>Tirzepatide<\/b><\/th>\n<th><b>Liraglutide<\/b><\/th>\n<th><b>Dulaglutide<\/b><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Heart risk reduction<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (diabetes and obesity)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (type 2 diabetes)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (type 2 diabetes)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (type 2 diabetes)<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Kidney protection<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (type 2 diabetes with kidney disease)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Not approved<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Not approved<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Not approved<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">MASH liver disease<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (Wegovy)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Not approved<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Not approved<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Not approved<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Sleep apnea<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Not approved<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (Zepbound)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Not approved<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Not approved<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Approved for teens with obesity<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (Wegovy, 12+)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes (Saxenda, 12+)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"semaglutide-vs-other-glp-1s-cost-in-2026\"><span style=\"font-weight: 400;\">Semaglutide vs other GLP-1s: cost in 2026<\/span><\/h2>\n<table>\n<thead>\n<tr>\n<th><b>Medication<\/b><\/th>\n<th><b>Typical self-pay price per month<\/b><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Wegovy pens<\/span><\/td>\n<td><span style=\"font-weight: 400;\">349(<\/span><span style=\"font-weight: 400;\">199 for the first 2 fills for new patients through December 31, 2026)<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Wegovy pill<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$149 to $299<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Ozempic<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$349 (up to 1 mg) or $499 (2 mg)<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Zepbound (LillyDirect)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$299 to $449<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Foundayo<\/span><\/td>\n<td><span style=\"font-weight: 400;\">From $149<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Liraglutide<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Varies by pharmacy; generics may cost less than brand<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Trulicity<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Usually covered for diabetes; list price around $1,000<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><i><span style=\"font-weight: 400;\">Prices as of October 2026 and subject to change.<\/span><\/i><\/p>\n<p><span style=\"font-weight: 400;\">For ways to lower your cost, see <\/span><a href=\"https:\/\/getheally.com\/patients\/news\/the-cost-of-semaglutide-for-weight-loss-and-where-to-find-discounts\"><span style=\"font-weight: 400;\">the cost of semaglutide and where to find discounts<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h2 id=\"which-glp-1-is-best-for-weight-loss\"><span style=\"font-weight: 400;\">Which GLP-1 is best for weight loss?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There&#8217;s no single best GLP-1 for everyone. A general guide:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Most weight loss:<\/b><span style=\"font-weight: 400;\"> Tirzepatide (Zepbound), or Wegovy HD for people already on semaglutide<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Heart disease without diabetes:<\/b><span style=\"font-weight: 400;\"> Semaglutide (Wegovy), with the strongest heart data<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Prefer a pill:<\/b><span style=\"font-weight: 400;\"> The Wegovy pill for more weight loss, or Foundayo for fewer rules about food<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Type 2 diabetes:<\/b><span style=\"font-weight: 400;\"> Semaglutide (Ozempic), tirzepatide (Mounjaro) or dulaglutide (Trulicity), depending on goals and coverage<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Lower cost or a daily option:<\/b><span style=\"font-weight: 400;\"> Generic liraglutide<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Sleep apnea:<\/b><span style=\"font-weight: 400;\"> Tirzepatide (Zepbound)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>MASH liver disease:<\/b><span style=\"font-weight: 400;\"> Semaglutide (Wegovy)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Your provider will also consider your health history, other medications, side effects and insurance. Some people ask about very low doses to limit side effects. See <\/span><a href=\"https:\/\/getheally.com\/patients\/news\/microdosing-glp-1-as-a-new-weight-loss-trend\"><span style=\"font-weight: 400;\">GLP-1 microdosing<\/span><\/a><span style=\"font-weight: 400;\"> for what the evidence shows.<\/span><\/p>\n<h2 id=\"the-bottom-line\"><span style=\"font-weight: 400;\">The bottom line<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Semaglutide is one of the most effective and versatile GLP-1 medications. It leads to much more weight loss than liraglutide and dulaglutide, and it has the most approved uses, including heart, kidney and liver benefits. It also comes as both a weekly injection and a daily pill. Tirzepatide leads to more weight loss on average, Foundayo is an easier-to-take pill and retatrutide may raise the bar further once approved. The best GLP-1 for you depends on your goals, health conditions and coverage.<\/span><\/p>\n<p><i><span style=\"font-weight: 400;\">Want help choosing between semaglutide and other GLP-1 options? <\/span><\/i><a href=\"https:\/\/getheally.com\/patients\/how-it-works\"><i><span style=\"font-weight: 400;\">See how Heally works<\/span><\/i><\/a><i><span style=\"font-weight: 400;\"> and talk to a licensed provider.<\/span><\/i><\/p>\n<h2 id=\"faq\"><span style=\"font-weight: 400;\">FAQ<\/span><\/h2>\n<h3 id=\"is-semaglutide-better-than-other-glp-1s\"><span style=\"font-weight: 400;\">Is semaglutide better than other GLP-1s?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Semaglutide leads to more weight loss than liraglutide and dulaglutide, and it has more approved uses than any other GLP-1. Tirzepatide, a dual GLP-1 and GIP drug, leads to more weight loss than semaglutide.<\/span><\/p>\n<h3 id=\"what-is-the-strongest-glp-1-for-weight-loss\"><span style=\"font-weight: 400;\">What is the strongest GLP-1 for weight loss?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Among approved medications, tirzepatide (Zepbound) leads to the most weight loss on average, about 20% to 21% in trials. Wegovy HD (semaglutide 7.2 mg) comes close. Retatrutide showed about 28% in a phase 3 trial but isn&#8217;t approved yet.<\/span><\/p>\n<h3 id=\"what-is-the-difference-between-semaglutide-and-liraglutide\"><span style=\"font-weight: 400;\">What is the difference between semaglutide and liraglutide?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Both are GLP-1 medications, but semaglutide is taken weekly and liraglutide daily. In the STEP 8 trial, semaglutide led to 15.8% weight loss vs 6.4% for liraglutide. Liraglutide is available as a generic.<\/span><\/p>\n<h3 id=\"is-trulicity-the-same-as-ozempic\"><span style=\"font-weight: 400;\">Is Trulicity the same as Ozempic?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">No. Trulicity contains dulaglutide and Ozempic contains semaglutide. Both are weekly GLP-1 injections for type 2 diabetes. In a head-to-head trial, Ozempic lowered blood sugar and weight more than Trulicity.<\/span><\/p>\n<h3 id=\"is-there-a-glp-1-pill-for-weight-loss\"><span style=\"font-weight: 400;\">Is there a GLP-1 pill for weight loss?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Yes. The Wegovy pill (oral semaglutide) and Foundayo (orforglipron) are both approved for weight loss. Rybelsus is a semaglutide pill approved for type 2 diabetes.<\/span><\/p>\n<h3 id=\"which-glp-1-medications-have-been-discontinued\"><span style=\"font-weight: 400;\">Which GLP-1 medications have been discontinued?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Exenatide (Byetta and Bydureon BCise) and lixisenatide (Adlyxin) are no longer sold in the US.<\/span><\/p>\n<h3 id=\"which-glp-1-has-the-fewest-side-effects\"><span style=\"font-weight: 400;\">Which GLP-1 has the fewest side effects?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Side effects are similar across GLP-1 medications and depend mostly on the dose and how fast it&#8217;s increased. In STEP 8, fewer people stopped semaglutide because of side effects than liraglutide.<\/span><\/p>\n<h2 id=\"sources\"><span style=\"font-weight: 400;\">Sources<\/span><\/h2>\n<ol>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rubino DM, et al. &#8220;Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial.&#8221; <\/span><i><span style=\"font-weight: 400;\">JAMA<\/span><\/i><span style=\"font-weight: 400;\">, 2022.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pratley RE, et al. &#8220;Semaglutide versus dulaglutide once weekly in patients with type 2 diabetes (SUSTAIN 7).&#8221; <\/span><i><span style=\"font-weight: 400;\">The Lancet Diabetes &amp; Endocrinology<\/span><\/i><span style=\"font-weight: 400;\">, 2018. <\/span><a href=\"https:\/\/www.thelancet.com\/journals\/landia\/article\/PIIS2213-8587%2818%2930024-X\/fulltext\"><span style=\"font-weight: 400;\">thelancet.com<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aronne LJ, et al. &#8220;Tirzepatide as Compared with Semaglutide for the Treatment of Obesity&#8221; (SURMOUNT-5). <\/span><i><span style=\"font-weight: 400;\">New England Journal of Medicine<\/span><\/i><span style=\"font-weight: 400;\">, 2025. <\/span><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2416394\"><span style=\"font-weight: 400;\">nejm.org<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Wilding JPH, et al. &#8220;Once-Weekly Semaglutide in Adults with Overweight or Obesity&#8221; (STEP 1). <\/span><i><span style=\"font-weight: 400;\">New England Journal of Medicine<\/span><\/i><span style=\"font-weight: 400;\">, 2021.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Eli Lilly and Company. &#8220;Lilly&#8217;s triple agonist, retatrutide, delivered powerful weight loss in pivotal Phase 3 obesity trial,&#8221; May 2026. <\/span><a href=\"https:\/\/investor.lilly.com\/news-releases\/news-release-details\/lillys-triple-agonist-retatrutide-delivered-powerful-weight-loss\"><span style=\"font-weight: 400;\">investor.lilly.com<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Eli Lilly and Company. &#8220;Foundayo (orforglipron) now available in the US,&#8221; April 2026. <\/span><a href=\"https:\/\/www.biospace.com\/press-releases\/foundayo-orforglipron-lillys-new-oral-glp-1-pill-for-weight-loss-now-available-in-the-u-s\"><span style=\"font-weight: 400;\">biospace.com<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">UnitedHealthcare. &#8220;Discontinuation of Bydureon BCise and Byetta,&#8221; 2024. <\/span><a href=\"https:\/\/www.uhcprovider.com\/en\/resource-library\/news\/2024\/discontinuation-bydureon-bcise-byetta.html\"><span style=\"font-weight: 400;\">uhcprovider.com<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cleveland Clinic. &#8220;GLP-1 agonists.&#8221; <\/span><a href=\"https:\/\/my.clevelandclinic.org\/health\/treatments\/13901-glp-1-agonists\"><span style=\"font-weight: 400;\">clevelandclinic.org<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Novo Nordisk. &#8220;Wegovy price guide,&#8221; April 2026. <\/span><a href=\"https:\/\/www.novocare.com\/content\/dam\/novonordisk\/novocare\/redesign\/pdf\/Wegovy_Price_Guide.pdf\"><span style=\"font-weight: 400;\">novocare.com<\/span><\/a><\/li>\n<\/ol>\n<p><i><span style=\"font-weight: 400;\">This article is for educational purposes only and is not a substitute for professional medical advice. GLP-1 medications are available by prescription only. Semaglutide, tirzepatide, liraglutide and dulaglutide carry an FDA boxed warning about the risk of thyroid C-cell tumors. Do not use them if you or a family member has had medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2.<\/span><\/i><\/p>\n","protected":false},"excerpt":{"rendered":"Semaglutide is one of the most effective GLP-1 medications for weight loss and type 2 diabetes. It&#8217;s also&hellip;\n","protected":false},"author":10,"featured_media":28822,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1841,1838,1794],"tags":[1860,2278,1793],"class_list":{"0":"post-28819","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-ozempic-weight-loss","8":"category-semaglutide-weight-loss","9":"category-weight-loss","10":"tag-glp-1","11":"tag-medication-comparison","12":"tag-semaglutide"},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Semaglutide vs other GLP-1 medications - Heally<\/title>\n<meta name=\"description\" content=\"Explore a thorough comparison of Semaglutide and other GLP-1 receptor agonists. 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