{"id":34129,"date":"2026-10-18T12:38:00","date_gmt":"2026-10-18T19:38:00","guid":{"rendered":"https:\/\/getheally.com\/patients\/news\/is-tirzepatide-worth-it-without-insurance-a-realistic-breakdown-of-costs-and-savings-tips-copy"},"modified":"2026-10-20T08:20:45","modified_gmt":"2026-10-20T15:20:45","slug":"why-some-people-lose-more-weight-on-tirzepatide-than-others-and-what-you-can-do-about-it","status":"publish","type":"post","link":"https:\/\/getheally.com\/patients\/news\/why-some-people-lose-more-weight-on-tirzepatide-than-others-and-what-you-can-do-about-it","title":{"rendered":"Why some people lose more weight on tirzepatide than others, and what you can do about it"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Tirzepatide results vary a lot from person to person. In the SURMOUNT-1 trial, 91% of people on the highest dose lost at least 5% of their body weight, but only about 36% lost 25% or more. The biggest differences come from dose, whether you have type 2 diabetes, sex, whether you add structured lifestyle support and, above all, whether you stay on treatment. Some of these you can&#8217;t change. Several you can. Here&#8217;s what the research shows about who loses the most, and how to improve your own results.<\/span><\/p>\n<h2 id=\"key-takeaways\"><span style=\"font-weight: 400;\">Key takeaways<\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">In SURMOUNT-1, average weight loss at 72 weeks was 15% on 5 mg, 19.5% on 10 mg and 20.9% on 15 mg<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">At 15 mg, 91% of people lost at least 5%, 57% lost at least 20% and 36% lost at least 25%<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">People with type 2 diabetes lost less on average, about 13% to 15% in SURMOUNT-2<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Women lost more than men in a pooled analysis of four SURMOUNT trials<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Adding intensive lifestyle support before starting led to 26.6% total weight loss in SURMOUNT-3<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">People who stayed on tirzepatide kept losing weight, while those who stopped regained 14% of their body weight<\/span><\/li>\n<\/ul>\n<h2 id=\"how-much-do-tirzepatide-results-vary\"><span style=\"font-weight: 400;\">How much do tirzepatide results vary?<\/span><\/h2>\n<p><a href=\"https:\/\/getheally.com\/patients\/weight-loss-info\/what-is-tirzepatide\"><span style=\"font-weight: 400;\">Tirzepatide<\/span><\/a><span style=\"font-weight: 400;\">, sold as <\/span><a href=\"https:\/\/getheally.com\/patients\/zepbound\"><span style=\"font-weight: 400;\">Zepbound<\/span><\/a><span style=\"font-weight: 400;\"> for weight management and <\/span><a href=\"https:\/\/getheally.com\/patients\/mounjaro\"><span style=\"font-weight: 400;\">Mounjaro<\/span><\/a><span style=\"font-weight: 400;\"> for type 2 diabetes, is one of the most effective weight loss medications available. But averages hide a wide range.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Here&#8217;s what SURMOUNT-1 found in 2,539 adults with obesity or overweight and no diabetes, after 72 weeks:<\/span><\/p>\n<table>\n<thead>\n<tr>\n<th><b>Weight loss reached<\/b><\/th>\n<th><b>5 mg<\/b><\/th>\n<th><b>10 mg<\/b><\/th>\n<th><b>15 mg<\/b><\/th>\n<th><b>Placebo<\/b><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span style=\"font-weight: 400;\">Average weight loss<\/span><\/td>\n<td><span style=\"font-weight: 400;\">15.0%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">19.5%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">20.9%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3.1%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Lost at least 5%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">85%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">89%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">91%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">35%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Lost at least 15%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">48%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">67%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">71%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">9%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Lost at least 20%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">30%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">50%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">57%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Lost at least 25%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">15%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">32%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">36%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">1.5%<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span style=\"font-weight: 400;\">These figures include everyone who started treatment, even those who stopped early. So the takeaway is clear: most people lose meaningful weight, a large share lose 20% or more, and a smaller group loses less than 5%.<\/span><\/p>\n<h2 id=\"who-tends-to-lose-more-weight-on-tirzepatide\"><span style=\"font-weight: 400;\">Who tends to lose more weight on tirzepatide<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Clinical trials point to five main factors.<\/span><\/p>\n<h3 id=\"1-people-on-higher-doses\"><span style=\"font-weight: 400;\">1. People on higher doses<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The table above shows a clear dose effect. The jump from 5 mg to 10 mg is the biggest. Going from 10 mg to 15 mg adds a smaller extra benefit on average, but some people respond much more at the top dose. For a dose-by-dose breakdown, see <\/span><a href=\"https:\/\/getheally.com\/patients\/news\/what-dose-of-zepbound-is-most-effective\"><span style=\"font-weight: 400;\">what dose of Zepbound is most effective<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3 id=\"2-people-without-type-2-diabetes\"><span style=\"font-weight: 400;\">2. People without type 2 diabetes<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">In SURMOUNT-2, which studied 938 adults with type 2 diabetes and overweight or obesity, average weight loss after 72 weeks was:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>12.8%<\/b><span style=\"font-weight: 400;\"> on 10 mg<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>14.7%<\/b><span style=\"font-weight: 400;\"> on 15 mg<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>3.2%<\/b><span style=\"font-weight: 400;\"> on placebo<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">That&#8217;s still substantial, but lower than in people without diabetes. Researchers think this may be partly because insulin resistance and some diabetes medications, such as insulin and sulfonylureas, make weight loss harder. Better blood sugar control is a major benefit in its own right.<\/span><\/p>\n<h3 id=\"3-women\"><span style=\"font-weight: 400;\">3. Women<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">A 2024 analysis in <\/span><i><span style=\"font-weight: 400;\">Diabetologia<\/span><\/i><span style=\"font-weight: 400;\"> pooled four SURMOUNT trials and 4,677 adults. Women lost up to 24.6% of their body weight, compared with up to 18.1% for men. The reasons aren&#8217;t fully understood, but differences in body composition and hormones likely play a role. Men can still see strong results. We look at this in <\/span><a href=\"https:\/\/getheally.com\/patients\/news\/weight-loss-injections-for-men-how-dosing-and-results-differ\"><span style=\"font-weight: 400;\">weight loss injections for men<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3 id=\"4-people-who-add-structured-lifestyle-support\"><span style=\"font-weight: 400;\">4. People who add structured lifestyle support<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">In SURMOUNT-3, participants first spent 12 weeks in an intensive lifestyle program and lost 6.9% of their weight. They then started tirzepatide or placebo. After another 72 weeks, those on tirzepatide had lost 26.6% of their starting weight in total, compared with 3.8% on placebo.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">That&#8217;s one of the largest average results in the SURMOUNT program. It suggests that building eating and activity habits alongside the medication pays off.<\/span><\/p>\n<h3 id=\"5-people-who-stay-on-treatment\"><span style=\"font-weight: 400;\">5. People who stay on treatment<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">This is the most important factor of all. In SURMOUNT-4, everyone took tirzepatide for 36 weeks and lost about 21% of their weight. Then half switched to placebo:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Those who stayed on tirzepatide<\/b><span style=\"font-weight: 400;\"> lost an additional 5.5% over the next year<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Those who switched to placebo<\/b><span style=\"font-weight: 400;\"> regained 14% of their body weight<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">People who stopped early simply didn&#8217;t get the full benefit. For more on what happens after you reach your goal, see <\/span><a href=\"https:\/\/getheally.com\/patients\/news\/can-you-stop-taking-tirzepatide-after-reaching-your-goal-weight\"><span style=\"font-weight: 400;\">can you stop taking tirzepatide after reaching your goal weight<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Support for better results: <\/span><a href=\"https:\/\/getheally.com\/patients\/test-for-weight-loss\"><span style=\"font-weight: 400;\">weight loss lab panel<\/span><\/a><span style=\"font-weight: 400;\"> \u00b7 <\/span><a href=\"https:\/\/getheally.com\/patients\/pcos-treatment\"><span style=\"font-weight: 400;\">PCOS treatment<\/span><\/a><span style=\"font-weight: 400;\"> \u00b7 <\/span><a href=\"https:\/\/getheally.com\/patients\/weight-loss-prescription\"><span style=\"font-weight: 400;\">weight loss prescription<\/span><\/a><\/p>\n<h2 id=\"factors-that-can-hold-your-results-back\"><span style=\"font-weight: 400;\">Factors that can hold your results back<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Beyond the trial findings, these common factors can limit weight loss:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Other medications.<\/b><span style=\"font-weight: 400;\"> Some antidepressants, antipsychotics, steroids, beta blockers and diabetes drugs like insulin can cause weight gain or slow weight loss.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Health conditions.<\/b><span style=\"font-weight: 400;\"> Hypothyroidism, polycystic ovary syndrome (PCOS), Cushing&#8217;s syndrome and untreated sleep apnea can all make weight loss harder.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Low protein intake and no strength training.<\/b><span style=\"font-weight: 400;\"> Losing muscle lowers your energy needs and can slow progress.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Liquid calories and frequent snacking.<\/b><span style=\"font-weight: 400;\"> Sugary drinks, alcohol and grazing can quietly offset the medication&#8217;s effect.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Poor sleep and high stress.<\/b><span style=\"font-weight: 400;\"> Both raise hunger hormones and cravings.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Metabolic adaptation.<\/b><span style=\"font-weight: 400;\"> As you lose weight, your body burns fewer calories, which naturally slows progress over time. We explain this in <\/span><a href=\"https:\/\/getheally.com\/patients\/news\/why-you-stop-losing-weight-metabolic-adaptation-explained\"><span style=\"font-weight: 400;\">why you stop losing weight<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<\/ul>\n<h2 id=\"what-you-can-do-to-get-more-from-tirzepatide\"><span style=\"font-weight: 400;\">What you can do to get more from tirzepatide<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">You can&#8217;t change your sex or diabetes status, but you can work on the factors the trials show matter most:<\/span><\/p>\n<ol>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Work up to an effective dose.<\/b><span style=\"font-weight: 400;\"> Many people stay too long on low doses. If side effects are manageable and progress has stalled, talk to your provider about stepping up.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Take every dose on time.<\/b><span style=\"font-weight: 400;\"> Missed doses let drug levels fall and appetite return. If you miss one, follow the 4-day rule in <\/span><a href=\"https:\/\/getheally.com\/patients\/news\/what-will-happen-if-you-skip-tirzepatide-dose\"><span style=\"font-weight: 400;\">what happens if you skip a tirzepatide dose<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Build habits from the start.<\/b><span style=\"font-weight: 400;\"> SURMOUNT-3 suggests lifestyle support adds to the medication&#8217;s effect. Focus on protein-first meals, fiber, fewer liquid calories and regular movement.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Protect your muscle.<\/b><span style=\"font-weight: 400;\"> Strength train at least three times a week and eat enough protein. See <\/span><a href=\"https:\/\/getheally.com\/patients\/news\/balancing-tirzepatide-with-your-fitness-goals-can-you-build-muscle-while-losing-fat\"><span style=\"font-weight: 400;\">building muscle while losing fat on tirzepatide<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Review your other medications<\/b><span style=\"font-weight: 400;\"> with your provider, especially if any are linked to weight gain.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Check for underlying conditions.<\/b><span style=\"font-weight: 400;\"> Lab tests can look for thyroid problems, insulin resistance and other issues that slow weight loss.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Give it time.<\/b><span style=\"font-weight: 400;\"> In a 2025 SURMOUNT analysis, weight typically didn&#8217;t plateau until 24 to 36 weeks, and later on higher doses. A slow first few months doesn&#8217;t mean the medication isn&#8217;t working.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Plan for the long term.<\/b><span style=\"font-weight: 400;\"> Staying on a maintenance dose protects your results, as SURMOUNT-4 showed.<\/span><\/li>\n<\/ol>\n<p><span style=\"font-weight: 400;\">For practical day-to-day tips, see <\/span><a href=\"https:\/\/getheally.com\/patients\/news\/why-some-people-lose-weight-faster-on-zepbound-than-others-and-how-to-optimize-your-results\"><span style=\"font-weight: 400;\">why some people lose weight faster on Zepbound and how to optimize your results<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h2 id=\"when-your-results-are-lower-than-expected\"><span style=\"font-weight: 400;\">When your results are lower than expected<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">If you&#8217;ve been on tirzepatide for several months, taken it consistently and still lost less than 5% of your body weight, talk to your provider. Options may include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increasing your dose, if you haven&#8217;t reached the maximum and side effects allow<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Checking labs and reviewing your other medications<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Getting more structured nutrition or activity support<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Considering a different medication if tirzepatide still isn&#8217;t working well for you<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">For a checklist of common causes, see <\/span><a href=\"https:\/\/getheally.com\/patients\/news\/why-are-you-not-losing-weight-on-tirzepatide\"><span style=\"font-weight: 400;\">why you might not be losing weight on tirzepatide<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h2 id=\"the-bottom-line\"><span style=\"font-weight: 400;\">The bottom line<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Tirzepatide works for most people, but the amount of weight lost varies widely. In trials, people on higher doses, people without type 2 diabetes, women, people who added structured lifestyle support and, most of all, people who stayed on treatment tended to lose the most. You can improve your own results by reaching an effective dose, taking every dose on time, building protein and strength habits, checking for underlying conditions and giving the medication time to work. If progress stalls, work with your provider to adjust your plan rather than giving up.<\/span><\/p>\n<p><i><span style=\"font-weight: 400;\">Want a plan built around your own response to tirzepatide? <\/span><\/i><a href=\"https:\/\/getheally.com\/patients\/tirzepatide\"><i><span style=\"font-weight: 400;\">Talk to a Heally provider through our tirzepatide program<\/span><\/i><\/a><i><span style=\"font-weight: 400;\">.<\/span><\/i><\/p>\n<h2 id=\"faq\"><span style=\"font-weight: 400;\">FAQ<\/span><\/h2>\n<h3 id=\"why-do-some-people-lose-more-weight-on-tirzepatide-than-others\"><span style=\"font-weight: 400;\">Why do some people lose more weight on tirzepatide than others?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Results depend on dose, whether you have type 2 diabetes, sex, lifestyle habits and how consistently you stay on treatment. In trials, people on higher doses, people without diabetes, women and people who stayed on tirzepatide tended to lose the most.<\/span><\/p>\n<h3 id=\"what-percentage-of-people-lose-weight-on-tirzepatide\"><span style=\"font-weight: 400;\">What percentage of people lose weight on tirzepatide?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">In SURMOUNT-1, 85% to 91% of people on tirzepatide lost at least 5% of their body weight over 72 weeks, depending on dose. At 15 mg, 57% lost at least 20% and about 36% lost at least 25%.<\/span><\/p>\n<h3 id=\"do-people-with-diabetes-lose-less-weight-on-tirzepatide\"><span style=\"font-weight: 400;\">Do people with diabetes lose less weight on tirzepatide?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">On average, yes. In SURMOUNT-2, adults with type 2 diabetes lost 12.8% on 10 mg and 14.7% on 15 mg over 72 weeks. That&#8217;s less than people without diabetes, but still substantial, and blood sugar control improves too.<\/span><\/p>\n<h3 id=\"do-women-lose-more-weight-on-tirzepatide-than-men\"><span style=\"font-weight: 400;\">Do women lose more weight on tirzepatide than men?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">In a pooled analysis of four SURMOUNT trials, women lost up to 24.6% of their body weight compared with up to 18.1% for men. Men still see strong results, especially on higher doses with consistent treatment.<\/span><\/p>\n<h3 id=\"what-can-i-do-if-tirzepatide-isnt-working-well-for-me\"><span style=\"font-weight: 400;\">What can I do if tirzepatide isn&#8217;t working well for me?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Make sure you&#8217;re on an effective dose and not missing doses, eat enough protein, strength train and limit liquid calories. Ask your provider to review your other medications and check for conditions like hypothyroidism. If progress is still slow, discuss a dose change or other options.<\/span><\/p>\n<h3 id=\"how-long-does-it-take-to-see-full-results-on-tirzepatide\"><span style=\"font-weight: 400;\">How long does it take to see full results on tirzepatide?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Months. In a 2025 analysis of SURMOUNT trials, weight typically didn&#8217;t plateau until 24 to 36 weeks, and later for people on higher doses. Most of the weight loss in trials happened over the full 72 weeks.<\/span><\/p>\n<h2 id=\"sources\"><span style=\"font-weight: 400;\">Sources<\/span><\/h2>\n<ol>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Jastreboff AM, et al. &#8220;Tirzepatide Once Weekly for the Treatment of Obesity&#8221; (SURMOUNT-1). <\/span><i><span style=\"font-weight: 400;\">New England Journal of Medicine<\/span><\/i><span style=\"font-weight: 400;\">, 2022. <\/span><a href=\"https:\/\/investor.lilly.com\/news-releases\/news-release-details\/lillys-surmount-1-results-published-new-england-journal-medicine\"><span style=\"font-weight: 400;\">investor.lilly.com summary<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Garvey WT, et al. &#8220;Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes&#8221; (SURMOUNT-2). <\/span><i><span style=\"font-weight: 400;\">The Lancet<\/span><\/i><span style=\"font-weight: 400;\">, 2023.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Wadden TA, et al. &#8220;Tirzepatide after intensive lifestyle intervention in adults with overweight or obesity: the SURMOUNT-3 phase 3 trial.&#8221; <\/span><i><span style=\"font-weight: 400;\">Nature Medicine<\/span><\/i><span style=\"font-weight: 400;\">, 2023. <\/span><a href=\"https:\/\/investor.lilly.com\/news-releases\/news-release-details\/lillys-tirzepatide-shows-additional-211-weight-loss-after-12\"><span style=\"font-weight: 400;\">investor.lilly.com summary<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aronne LJ, et al. &#8220;Continued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity: The SURMOUNT-4 Randomized Clinical Trial.&#8221; <\/span><i><span style=\"font-weight: 400;\">JAMA<\/span><\/i><span style=\"font-weight: 400;\">, 2024. <\/span><a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2812936\"><span style=\"font-weight: 400;\">jamanetwork.com<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Garcia LE, et al. Sex differences in weight reduction with tirzepatide, post hoc analysis of SURMOUNT-1 to -4. <\/span><i><span style=\"font-weight: 400;\">Diabetologia<\/span><\/i><span style=\"font-weight: 400;\">, 2024. <\/span><a href=\"https:\/\/www.eurekalert.org\/news-releases\/1057347\"><span style=\"font-weight: 400;\">eurekalert.org<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Horn DB, Kahan S, et al. &#8220;Time to weight plateau with tirzepatide treatment in the SURMOUNT-1 and SURMOUNT-4 clinical trials.&#8221; <\/span><i><span style=\"font-weight: 400;\">Clinical Obesity<\/span><\/i><span style=\"font-weight: 400;\">, 2025.<\/span><\/li>\n<\/ol>\n<p><i><span style=\"font-weight: 400;\">This article is for educational purposes only and is not a substitute for professional medical advice. Individual results vary. Tirzepatide is available by prescription only and carries an FDA boxed warning about the risk of thyroid C-cell tumors. Do not use it if you or a family member has had medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2.<\/span><\/i><\/p>\n","protected":false},"excerpt":{"rendered":"Tirzepatide results vary a lot from person to person. 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