{"id":37282,"date":"2026-04-23T07:15:55","date_gmt":"2026-04-23T14:15:55","guid":{"rendered":"https:\/\/getheally.com\/patients\/news\/?p=37282"},"modified":"2026-04-27T15:06:13","modified_gmt":"2026-04-27T22:06:13","slug":"nad-sleep-circadian-rhythm-melatonin","status":"publish","type":"post","link":"https:\/\/getheally.com\/patients\/news\/nad-sleep-circadian-rhythm-melatonin","title":{"rendered":"NAD+ for Sleep: Circadian Rhythm &amp; Melatonin Effects"},"content":{"rendered":"<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">The link between NAD+ sleep quality and overall health is getting more attention, and for good reason. <a href=\"https:\/\/getheally.com\/patients\/nad-injection\">NAD+<\/a> is a naturally occurring molecule in the body that may influence how well you sleep, including your sleep cycles, melatonin levels, and ability to stay asleep through the night. This guide explores what we currently know about NAD+ and sleep, and whether it may be a useful option for those struggling with rest.<\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"><strong>Key Takeaways:<\/strong><\/p>\n<ul class=\"[li_&amp;]:mb-0 [li_&amp;]:mt-1 [li_&amp;]:gap-1 [&amp;:not(:last-child)_ul]:pb-1 [&amp;:not(:last-child)_ol]:pb-1 list-disc flex flex-col gap-1 pl-8 mb-3\">\n<li class=\"whitespace-normal break-words pl-2\">NAD+ plays important roles in circadian rhythm regulation through sirtuin activation and cellular energy metabolism<\/li>\n<li class=\"whitespace-normal break-words pl-2\">May support natural melatonin production by influencing enzymes and pathways involved in melatonin synthesis<\/li>\n<li class=\"whitespace-normal break-words pl-2\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7963035\/\">Early research<\/a> and user experiences suggest potential sleep quality improvements, though large-scale studies are limited<\/li>\n<li class=\"whitespace-normal break-words pl-2\">Works differently than traditional sleep aids by addressing underlying cellular and metabolic factors<\/li>\n<li class=\"whitespace-normal break-words pl-2\">Should be considered as part of comprehensive sleep optimization rather than a standalone solution<\/li>\n<\/ul>\n<h3 id=\"the-science-of-sleep-what-controls-your-circadian-rhythm\" class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\">The Science of Sleep: What Controls Your Circadian Rhythm<\/h3>\n<h4 id=\"your-internal-biological-clock\" class=\"text-text-100 mt-2 -mb-1 text-base font-bold\">Your Internal Biological Clock<\/h4>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Sleep operates on an internal 24-hour cycle called the circadian rhythm that regulates when you feel alert or sleepy. This biological clock is controlled by the suprachiasmatic nucleus (SCN), a tiny region in your brain&#8217;s hypothalamus. The SCN responds to light exposure through your eyes, adjusting your internal clock to match the day-night cycle.<\/p>\n<h4 id=\"sirtuins-and-circadian-regulation\" class=\"text-text-100 mt-2 -mb-1 text-base font-bold\">Sirtuins and Circadian Regulation<\/h4>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Sirtuins are proteins that play crucial roles in regulating circadian rhythms. These proteins require NAD+ to function properly. They influence the expression of clock genes that control your sleep-wake cycle. When sirtuin activity is optimal, circadian rhythms tend to be more stable and consistent.<\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Sirtuins also help regulate cellular metabolism, energy production, and stress responses, all of which indirectly affect sleep quality. When cells function efficiently and metabolic processes run smoothly, the body is better positioned for restorative sleep.<\/p>\n<h4 id=\"melatonin-production-and-release\" class=\"text-text-100 mt-2 -mb-1 text-base font-bold\">Melatonin Production and Release<\/h4>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">One of the key ways NAD+ may influence sleep is through its relationship with proteins called sirtuins. Sirtuins help regulate the body&#8217;s internal clock, but they can only function properly when NAD+ levels are sufficient. When NAD+ is low, sirtuin activity drops, and the signals that control your sleep-wake cycle can become disrupted.<\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Think of it this way: NAD+ helps keep the biological gears of your circadian rhythm turning smoothly. Without enough of it, those gears can fall out of sync, potentially making it harder to fall asleep, stay asleep, or wake feeling rested.<\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Supporting NAD+ levels through subcutaneous injections, oral precursors, or other forms of therapy may help restore sirtuin function and, in turn, support more consistent and restorative sleep patterns.<\/p>\n<h3 id=\"how-nad-interacts-with-circadian-rhythm-and-sleep-hormones\" class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\">How NAD+ Interacts with Circadian Rhythm and Sleep Hormones<\/h3>\n<h4 id=\"nad-and-sirtuin-activation\" class=\"text-text-100 mt-2 -mb-1 text-base font-bold\">NAD+ and Sirtuin Activation<\/h4>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">The connection between NAD circadian rhythm regulation centers largely on sirtuins. These proteins cannot function without NAD+. When NAD+ levels are adequate, sirtuins can properly regulate clock genes that control circadian rhythms.<\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(13)00594-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867413005941%3Fshowall%3Dtrue\">Research<\/a> shows that sirtuins, particularly SIRT1, directly influence the molecular clock by modulating the activity of clock proteins. This affects the timing and strength of circadian rhythms. When sirtuin function is impaired due to low NAD+ levels, circadian rhythms can become dysregulated, potentially contributing to sleep problems.<\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">By supporting NAD+ levels through subcutaneous injection, supplementation, or IV therapy, sirtuin function may improve, potentially leading to better circadian rhythm regulation and more consistent sleep-wake patterns.<\/p>\n<h4 id=\"nad-and-melatonin-synthesis\" class=\"text-text-100 mt-2 -mb-1 text-base font-bold\">NAD+ and Melatonin Synthesis<\/h4>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">The relationship between NAD melatonin production involves several pathways. Melatonin synthesis requires the conversion of serotonin through specific enzymatic steps. These enzymes need adequate cellular energy (ATP) and various cofactors to function optimally.<\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">NAD+ is essential for cellular energy production through mitochondrial respiration. When cells have adequate energy, all their functions, including hormone synthesis, work more efficiently. Additionally, NAD+ is involved in the metabolism of tryptophan, the amino acid precursor to both serotonin and melatonin.<\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10665902\/\">Some research suggests<\/a> that NAD+ levels themselves follow a circadian pattern, being higher during waking hours and declining at night. This rhythm may influence melatonin production timing.<\/p>\n<h4 id=\"cellular-energy-and-sleep-quality\" class=\"text-text-100 mt-2 -mb-1 text-base font-bold\">Cellular Energy and Sleep Quality<\/h4>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Beyond specific effects on circadian genes and melatonin, NAD+&#8217;s fundamental role in cellular energy production affects sleep quality. During sleep, your body performs critical repair and maintenance functions. These processes require energy. When cells have adequate NAD+ for efficient energy production, repair processes can proceed optimally, potentially translating to more restorative sleep.<\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">NAD+ also supports mitochondrial health. Since mitochondria are the powerhouses producing cellular energy, healthy mitochondrial function is essential for all body processes, including those that occur during sleep. Oxidative stress and inflammation can disrupt sleep. NAD+ supports enzymes involved in managing oxidative stress and influences inflammatory pathways, potentially contributing to better sleep.<\/p>\n<h3 id=\"does-nad-help-people-sleep-better\" class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\">Does NAD+ Help People Sleep Better?<\/h3>\n<h4 id=\"research-evidence\" class=\"text-text-100 mt-2 -mb-1 text-base font-bold\">Research Evidence<\/h4>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7963035\/\">Scientific research on NAD<\/a> and sleep quality remains limited but growing. Most studies examining NAD+ have focused on aging, metabolism, or neurological health rather than sleep specifically. However, some findings are relevant.<\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Studies on sirtuins and circadian rhythms demonstrate that these proteins influence sleep-wake cycles. Since NAD+ is required for sirtuin function, this suggests NAD+ levels could affect sleep patterns. Animal studies have shown connections between NAD+ metabolism and circadian rhythms. Mice with disrupted NAD+ metabolism show altered sleep patterns and circadian dysfunction.<\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">More research specifically examining NAD&#8217;s effects on human sleep quality is needed before definitive conclusions can be drawn.<\/p>\n<h4 id=\"anecdotal-reports-and-clinical-observations\" class=\"text-text-100 mt-2 -mb-1 text-base font-bold\">Anecdotal Reports and Clinical Observations<\/h4>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Healthcare providers offering NAD+ report that many patients mention improved sleep quality among the benefits they experience. Common reports include falling asleep more easily, waking up feeling more rested, experiencing fewer middle-of-the-night awakenings, and having more vivid or memorable dreams.<\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">However, anecdotal reports have limitations. Placebo effects are strong with sleep interventions. People investing in NAD+ may simultaneously make other sleep-supporting changes. Individual variation is enormous, with some people reporting dramatic improvements and others noticing little change.<\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">People often report that they feel more rested after the same amount of sleep or that they wake fewer times during the night. Some report needing slightly less sleep to feel fully rested, possibly because their sleep is more efficient and restorative.<\/p>\n<h3 id=\"nad-vs-traditional-sleep-aids\" class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\">NAD+ vs Traditional Sleep Aids<\/h3>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Melatonin supplements directly provide the sleep hormone, bypassing your body&#8217;s natural production. This can help with jet lag or short-term sleep issues, but long-term reliance may affect natural production. NAD+ takes a different approach by potentially supporting your body&#8217;s natural melatonin production rather than replacing it.<\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Prescription sleep medications like benzodiazepines or Z-drugs work by directly affecting brain chemistry to induce drowsiness. They typically work quickly and reliably but often come with side effects, including next-day grogginess, potential dependency, and tolerance requiring increasing doses.<\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">NAD+ doesn&#8217;t directly induce sleep like these medications. Instead, it aims to support the underlying cellular and metabolic processes that enable natural, healthy sleep. Effects may be subtler and take longer to develop, but potentially without the downsides of sleep medications.<\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Many natural approaches support sleep, including magnesium, L-theanine, glycine, valerian root, and various adaptogens. NAD+ differs from these by working at a more fundamental cellular level rather than through specific calming or sedating mechanisms. It could potentially be combined with these other natural supports as part of a comprehensive sleep optimization approach.<\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">The foundation of good sleep is sleep hygiene, including a consistent sleep schedule, a dark and cool bedroom, limited evening screen time, regular exercise, and stress management. NAD+ should complement, not replace, these fundamental practices.<\/p>\n<h3 id=\"is-nad-safe-for-people-with-sleep-disorders\" class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\">Is NAD+ Safe for People with Sleep Disorders?<\/h3>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">NAD+ has been used for various purposes with generally good safety profiles when administered properly. Common side effects are typically mild and include nausea (especially if infused too quickly), flushing or warmth, headache, or temporary anxiety or jitteriness. These effects are usually managed by adjusting infusion speed or dose.<\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">People with diagnosed sleep disorders, including insomnia, sleep apnea, restless leg syndrome, or circadian rhythm disorders, should approach NAD+ with appropriate medical guidance. While NAD+ may help, it shouldn&#8217;t replace established treatments for these conditions.<\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Some people report feeling energized after NAD+ injection, which raises questions about optimal timing. Many practitioners recommend NAD+ injections earlier in the day rather than in the evening, though individual responses vary. Oral NAD+ precursors like NR (nicotinamide riboside) or NMN (nicotinamide mononucleotide) can be timed based on individual response and practitioner guidance.<\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Anyone considering NAD+, especially for sleep issues, should work with healthcare providers experienced in this treatment. Proper evaluation helps ensure NAD+ dosage and administration are optimized for individual needs, while potential interactions with other treatments are considered.<\/p>\n<h3 id=\"how-to-try-nad-for-better-sleep\" class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\">How to Try NAD+ for Better Sleep<\/h3>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"><strong>NAD+ Subcutaneous Injections<\/strong><\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"><a href=\"https:\/\/getheally.com\/patients\/nad-injection\">Subcutaneous NAD+ injections<\/a> deliver NAD+ directly into the tissue just beneath the skin, offering a more convenient and accessible alternative to IV infusions. They can be self-administered at home once a provider has established your protocol, making them a practical option for ongoing use. Doses and frequency vary based on individual needs and goals, so working with a healthcare provider to find the right starting point is important.<\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Some people begin with more frequent injections to build up cellular NAD+ levels, then transition to a less frequent maintenance schedule over time.<\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"><strong>Oral NAD+ Precursors<\/strong><\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Oral supplements don&#8217;t provide NAD+ directly but supply precursors that the body converts to NAD+. Common options include nicotinamide riboside (NR), typically 250mg to 500mg daily, and nicotinamide mononucleotide (NMN), typically 250mg to 1000mg daily.<\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">These supplements are more accessible and affordable than the injectable form but achieve lower NAD+ increases. Some people use oral precursors daily for general support and add occasional injections for more intensive benefits.<\/p>\n<h4 id=\"lifestyle-support-for-nad-levels\" class=\"text-text-100 mt-2 -mb-1 text-base font-bold\">Lifestyle Support for NAD+ Levels<\/h4>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Certain lifestyle practices may help maintain healthy NAD+ levels, including regular exercise, caloric restriction or time-restricted eating, managing stress, avoiding excessive alcohol, and getting adequate sleep. Combining NAD+ with these practices may enhance benefits.<\/p>\n<h3 id=\"conclusion\" class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\">Conclusion<\/h3>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">The relationship between NAD+ and sleep involves complex biological mechanisms, including circadian rhythm regulation through sirtuins, potential support for natural melatonin production, cellular energy optimization for restorative sleep processes, and management of oxidative stress and inflammation that can disrupt sleep.<\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">While research specifically on NAD+ for sleep improvement remains limited, the biological mechanisms are plausible, and early evidence is encouraging. Many people using NAD+ for various health reasons report better sleep as a secondary benefit.<\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">However, NAD+ should not be viewed as a magic bullet for sleep problems. It works best as part of a comprehensive sleep optimization that includes good sleep hygiene, stress management, appropriate treatment of underlying sleep disorders, and attention to nutrition and lifestyle factors.<\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">The safety profile of NAD+ appears favorable when properly administered, though individual responses vary. Working with experienced healthcare providers ensures appropriate evaluation, treatment planning, and monitoring.<\/p>\n<h4 id=\"access-through-heally\" class=\"text-text-100 mt-2 -mb-1 text-base font-bold\">Access Through Heally<\/h4>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">At Heally, our healthcare providers can evaluate whether NAD+ makes sense for your sleep concerns and overall health goals. We offer a comprehensive assessment of sleep issues and contributing factors, guidance on whether NAD+ injections or oral precursors are most appropriate, administration of NAD+ with proper dosing and monitoring, and integration with other sleep optimization strategies.<\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">We understand that sleep problems rarely have a single cause. Our approach considers NAD+ as one potential component of comprehensive sleep improvement rather than an isolated intervention.<\/p>\n<p>Ready to explore whether NAD+ might help improve your sleep quality? <a href=\"https:\/\/md.getheally.com\/f\/vshop-book_appt?visit_type_id=307\">Schedule a consultation with Heally today.<\/a><\/p>\n<h2 id=\"\" data-start=\"6519\" data-end=\"6536\">\u00a0<\/h2>\n<h2 id=\"sources\">Sources<\/h2>\n<ul>\n<li>Frontiers: <a href=\"https:\/\/www.frontiersin.org\/journals\/aging-neuroscience\/articles\/10.3389\/fnagi.2019.00257\/full\">A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+<\/a><\/li>\n<li>PubMed Central: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7963035\/\">NAD+ metabolism and its roles in cellular processes during ageing<\/a><\/li>\n<li>PubMed Central: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9512238\/\">The Role of NAD+ in Regenerative Medicine<\/a><\/li>\n<li>Aging and Disease: <a href=\"https:\/\/www.aginganddisease.org\/EN\/10.14336\/AD.2021.0824\">The Role of Kynurenine Pathway and NAD+ Metabolism in Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome<\/a><\/li>\n<li>Cell: <a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(13)00594-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867413005941%3Fshowall%3Dtrue\">SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging<\/a><\/li>\n<li>BMC Part of Springer Nature &#8211; Journal of Neuroinflammation: <a href=\"https:\/\/jneuroinflammation.biomedcentral.com\/articles\/10.1186\/s12974-021-02250-8\">NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1\/PGC-1\u03b1 pathway<\/a><\/li>\n<li>NIH: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24786309\/\">NAD+ and sirtuins in aging and disease<\/a><\/li>\n<li>NIH: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10665902\/\">Effect of circadian rhythm on NAD and other metabolites in human brain<\/a><\/li>\n<li>Frontiers: <a href=\"https:\/\/www.frontiersin.org\/journals\/nutrition\/articles\/10.3389\/fnut.2023.1208734\/full\">The effects of NAD+ precursor (nicotinic acid and nicotinamide) supplementation on weight loss and related hormones: a systematic review and meta-regression analysis of randomized controlled trials<\/a><\/li>\n<li>Nature: <a href=\"https:\/\/www.nature.com\/articles\/s41392-020-00354-w\">NAD+ metabolism, stemness, the immune response, and cancer<\/a><\/li>\n<li>PudMed Central: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9734213\/\">NAD+ Therapeutics and Skeletal Muscle Adaptation to Exercise in Humans<\/a><\/li>\n<\/ul>\n<p><strong>Educational Disclaimer: This content is for informational purposes only and is not intended to provide medical advice, diagnosis, or treatment recommendations. Individual experiences may vary significantly. Always consult with a qualified healthcare provider before making decisions about any supplement or treatment approach.<\/strong><\/p>\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"The link between NAD+ sleep quality and overall health is getting more attention, and for good reason. NAD+&hellip;\n","protected":false},"author":7,"featured_media":37299,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[116,1823,1854],"tags":[2135,1957,2949,1861,1862,2948,2133,2391,1765],"class_list":{"0":"post-37282","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-health-and-wellness","8":"category-longevity","9":"category-nad","10":"tag-how-nad-works","11":"tag-muscle-loss","12":"tag-muscle-performance","13":"tag-nad","14":"tag-nad-benefits","15":"tag-nad-metabolism","16":"tag-nad-explained","17":"tag-performance","18":"tag-weight-loss"},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>NAD+ Sleep: Circadian Rhythm &amp; Melatonin Effects<\/title>\n<meta name=\"description\" content=\"Learn how NAD+ affects sleep through circadian rhythm regulation and melatonin production, including research and benefits.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/getheally.com\/patients\/news\/nad-sleep-circadian-rhythm-melatonin\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NAD+ Sleep: Circadian Rhythm &amp; 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