Longevity 101
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What is Cellular Senescence?

Cellular senescence describes a state in which cells cease to divide but do not die, contributing to aging and age-related disorders. Targeting and removing senescent cells to improve tissue function and delay aging manifestations is a promising strategy in anti-aging medicine, with the potential to enhance health and longevity.

Cellular senescence is when cells stop dividing and enter a state where they're still active but no longer capable of proliferation. This usually occurs as a protective mechanism to prevent the spread of damaged DNA that could potentially lead to diseases like cancer. However, as these senescent cells accumulate over time, they can start secreting harmful substances that cause inflammation and damage surrounding tissues, contributing to aging and various age-related diseases.

Addressing cellular senescence is becoming a key focus in anti-aging research. Scientists are exploring ways to clear these non-dividing cells from the body or to minimize their harmful effects. This research has led to the development of drugs known as senolytics, which specifically target and destroy senescent cells. Early studies suggest that reducing senescent cell burden can improve healthspan, reduce age-related ailments, and even extend lifespan, offering new potential strategies for extending healthy years in life.

Related terms

Telomeres

Telomeres, the protective caps at the end of chromosomes, play a crucial role in cellular aging. Their gradual shortening with each cell division leads to cellular senescence and aging. Research into telomere extension and protection offers the possibility of slowing the aging process, with implications for increasing healthspan and preventing age-related diseases.

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Fisetin

Fisetin is a flavonoid with anti-inflammatory and antioxidant properties, found in fruits and vegetables. It has shown promise in clearing senescent cells, reducing age-related pathology, and potentially extending lifespan, making it a compound of interest in longevity research.

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Rejuvenation

Rejuvenation involves medical and scientific interventions designed to reverse aging signs and restore youthful function and appearance to the body. By targeting the underlying causes of aging at the cellular and molecular levels, rejuvenation techniques seek to enhance overall well-being, reduce age-related diseases, and extend healthy lifespan, offering a promising outlook for aging individuals.

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