Longevity Terms and Researches Guide

Welcome to Longevity 101, your comprehensive guide to understanding the science and strategies behind extending human lifespan and improving healthspan. Dive into the biology of aging, explore the latest research on anti-aging interventions, and compare different approaches to longevity. Whether you're a healthcare professional or someone seeking knowledge, this page is your go-to resource for all things related to longevity and healthy aging.

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Anti-aging Medicine

Anti-aging medicine aims to extend the lifespan and improve the quality of life through the prevention, detection, and treatment of age-related conditions. It incorporates various strategies, including lifestyle modifications, hormone replacements, and cutting-edge technologies, to combat the biological effects of aging, striving to maintain vigor and vitality into later years.

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Rejuvenation involves medical and scientific interventions designed to reverse aging signs and restore youthful function and appearance to the body. By targeting the underlying causes of aging at the cellular and molecular levels, rejuvenation techniques seek to enhance overall well-being, reduce age-related diseases, and extend healthy lifespan, offering a promising outlook for aging individuals.

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Longevity refers to the science and practice of extending the human lifespan, focusing not only on adding years to life but also life to those years through improved health and vitality. Research in longevity seeks to understand the genetic, environmental, and lifestyle factors that contribute to a longer, healthier life, emphasizing preventive medicine and healthy aging strategies.

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Anti-aging Medications

Anti-aging medications are pharmaceuticals developed to slow down or reverse the aging process, targeting specific biological pathways associated with aging. These drugs aim to improve healthspan, the portion of life spent in good health, by addressing conditions like oxidative stress, inflammation, and cellular aging, offering potential benefits for longevity and quality of life.

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Rapamycin, a drug discovered for its immunosuppressive properties, has gained attention for its potential to extend lifespan by inhibiting the mTOR pathway, crucial in the aging process. Studies suggest rapamycin can delay aging in several species by enhancing autophagy and reducing cellular damage, offering insights into its application for human longevity.

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Metformin is a well-established medication for type 2 diabetes that has shown promising anti-aging effects. By improving insulin sensitivity and mimicking the benefits of caloric restriction, metformin is being researched for its potential to extend lifespan and prevent age-related diseases, making it a subject of significant interest in the field of longevity.

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Current research observation about longevity

Anti-Aging Drugs and the Related Signal Pathways


Nannan Du, Ruigang Yang, Shengrong Jiang, Zubiao Niu, Wenzhao Zhou, Chenyu Liu, Lihua Gao, Qiang Sun

This comprehensive review article focuses on the development of anti-aging drugs and the signal pathways they target, highlighting the significant progress in the field of aging and longevity. The article begins by setting the context of aging as a complex, multifactorial process that leads to the manifestation of various chronic diseases. The research emphasizes that, despite the diversity in their mechanisms, anti-aging drugs commonly aim to mitigate the effects of aging by targeting specific cellular signaling pathways.

Among the pathways discussed, the mechanistic target of rapamycin (mTOR), AMP-activated protein kinase (AMPK), and silent information regulator factor 2-related enzyme 1 (SIRT1) pathways are notable for their pivotal roles in cellular aging processes. Each pathway has associated drugs like rapamycin, metformin, and others which are believed to confer benefits such as delayed aging, reduced incidence of age-related diseases, and improved systemic health.

The article further delves into the challenges and potential side effects associated with these drugs, emphasizing the necessity for ongoing research to balance efficacy and safety. The authors advocate for a nuanced understanding of how these pathways interconnect and influence aging, proposing that future therapies might involve combinations of drugs to target multiple pathways simultaneously, thus offering a more holistic approach to delaying the aging process and enhancing life quality in the elderly population.

Human Trials Exploring Anti-Aging Medicines


Leonard Guarente, David A. Sinclair, Guido Kroemer

The research article "Human Trials Exploring Anti-Aging Medicines" provides a comprehensive overview of the latest advancements in anti-aging treatments, focusing on both drugs and natural compounds. The authors analyze the efficacy and safety of several anti-aging substances that have undergone clinical trials. Notably, they discuss the promising results of substances like rapamycin, resveratrol, and NAD+ boosters, which have shown potential in extending healthspan and reducing age-related diseases. For example, metformin, traditionally used for diabetes management, has shown promise in extending health span in animal models and is now being tested in humans for various aging-related outcomes.

The study highlights the mechanisms through which these compounds exert their effects, such as activation of specific genes related to longevity and improvement in cellular functions. Key findings include the extension of healthspan in human subjects, reduction in biomarkers associated with aging, and improved metabolic health. The authors also address the challenges in translating these results from controlled clinical settings to real-world applications. Importantly, the research emphasizes the need for further large-scale studies to confirm these findings and to determine optimal dosages and treatment regimens for broader human use.

Anti-Aging Potential of Ketone Ester Supplementation


Vana Stojić, Tea Štrbac, Andrija Stanimirović

Ketone ester supplementation has been increasingly recognized for its potential anti-aging effects. This study explores the implications of ketone esters, specifically β-hydroxybutyrate (β-HB), on aging and longevity. The research highlights that ketone esters promote a state of ketosis without the strict dietary restrictions typically associated with ketogenic diets, making it a more accessible intervention for aging populations.

The BIKE (Buck Institute Ketone Ester) pilot study is particularly noteworthy as it represents the first human clinical trial to assess the anti-aging effects of ketone ester supplementation in individuals over 65. This 12-week, double-blind, randomized, placebo-controlled trial aims to determine if the positive outcomes observed in mice—such as extended lifespan and improved health markers—translate to humans. Participants undergo various physical and mental tests, and their biological markers are monitored throughout the study.

The results from this pioneering study could significantly influence future dietary recommendations and therapeutic interventions aimed at mitigating the effects of aging, thereby enhancing the quality of life for the elderly population.

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