Longevity 101
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What is NAD+ (Nicotinamide Adenine Dinucleotide)?

NAD+ is vital for energy metabolism, DNA repair, and cell survival, but its levels decline with age. Boosting NAD+ through supplementation or other means could reverse aspects of aging and improve cellular function, making it a key target in the quest for increased longevity and better health in later years.

NAD+ is a molecule found in every cell of the body and plays a critical role in generating energy and maintaining cellular health. As we age, levels of NAD+ naturally decline, which is linked to aging and many chronic diseases. This decline in NAD+ impairs the function of mitochondria, the powerhouses of the cells, leading to decreased energy production and increased vulnerability to stress and damage.

Research into boosting NAD+ levels is a promising area in the field of aging. Increasing NAD+ can potentially reverse some aspects of aging and improve metabolic functions, mimicking the effects of calorie restriction—a known strategy for extending lifespan. Supplements that boost NAD+, such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), are currently being studied for their potential to enhance healthspan and treat age-related diseases by restoring cellular energy levels.

Related terms

Mitochondrial Dysfunction

Mitochondrial dysfunction, characterized by decreased energy production and increased oxidative stress, is a hallmark of aging. Improving mitochondrial health through dietary supplements, exercise, and medications like coenzyme Q10, is under study for its potential to delay aging and prevent chronic diseases associated with aging.

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Resveratrol

Resveratrol, found in grapes and red wine, has been noted for its potential to activate sirtuins, proteins involved in longevity and metabolic regulation. By mimicking the effects of calorie restriction and protecting against metabolic diseases, resveratrol is investigated for its role in promoting a longer, healthier life.

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Rejuvenation

Rejuvenation involves medical and scientific interventions designed to reverse aging signs and restore youthful function and appearance to the body. By targeting the underlying causes of aging at the cellular and molecular levels, rejuvenation techniques seek to enhance overall well-being, reduce age-related diseases, and extend healthy lifespan, offering a promising outlook for aging individuals.

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