Longevity 101
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What is Rapamycin?

Rapamycin, a drug discovered for its immunosuppressive properties, has gained attention for its potential to extend lifespan by inhibiting the mTOR pathway, crucial in the aging process. Studies suggest rapamycin can delay aging in several species by enhancing autophagy and reducing cellular damage, offering insights into its application for human longevity.

Rapamycin, originally developed as an immunosuppressant for transplant patients, has become widely recognized for its potential lifespan-extending properties. It inhibits the mTOR (mechanistic target of rapamycin) pathway, which is central to cell growth and metabolism. By inhibiting this pathway, rapamycin has been shown to mimic the life-extending effects of caloric restriction without the need to alter dietary habits drastically.

In various animal models, rapamycin has effectively delayed the onset of aging-related diseases and extended lifespan, suggesting similar potential in humans. It is currently used in medicine to prevent organ transplant rejection and treat certain cancers, but its role in anti-aging therapy is being actively explored. Researchers are investigating the optimal dosing and potential side effects of long-term rapamycin use to maximize its benefits for aging and healthspan.

Related terms

Spermidine

Spermidine, a naturally occurring polyamine found in foods like aged cheese, mushrooms, and soybeans, has been linked to cellular autophagy, a process vital for removing damaged cell components and supporting cellular renewal. Studies suggest spermidine supplementation may extend lifespan and improve cardiovascular health by enhancing cellular function and reducing inflammation, positioning it as a promising compound in longevity research.

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Mitochondrial Dysfunction

Mitochondrial dysfunction, characterized by decreased energy production and increased oxidative stress, is a hallmark of aging. Improving mitochondrial health through dietary supplements, exercise, and medications like coenzyme Q10, is under study for its potential to delay aging and prevent chronic diseases associated with aging.

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Anti-aging Medications

Anti-aging medications are pharmaceuticals developed to slow down or reverse the aging process, targeting specific biological pathways associated with aging. These drugs aim to improve healthspan, the portion of life spent in good health, by addressing conditions like oxidative stress, inflammation, and cellular aging, offering potential benefits for longevity and quality of life.

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