Soaking It Up: CBD & Cannabis Bioavailability

Bioavailability Cannabis

An important thing to consider when trying Cannabis or CBD is the method of use. Different methods of consumption result in different rates of bioavailability. Essentially, this is how much of a compound is available for use after it enters the bloodstream.


Alveoli Lungs VapingHow Long Does it Take to Feel Effects?

With dried cannabis flower and vaped concentrates, bioavailability is relatively high. CBD and other cannabinoids enter the bloodstream very fast when inhaled. They move through the alveoli in the lungs and become available for the body to use. It’s one of the reasons users notice such immediate effects from smoked and vaped cannabis. If someone is vaping CBD, they don’t need to eat to maximize the absorption of cannabinoids.

Cannabinoids in tincture form, are recommended to be taken sublingually, or under the tongue. When taken in this method, effects can be achieved within 10-15 minutes. The amount of dose percentage absorbed is also higher than other oral methods. That is because the sublingual gland processes compounds differently.

Oral ingestion of CBD and other cannabinoids takes a lot longer to take effect. This is because the cannabinoids have to be processed through the digestive system. When someone takes a capsule, the cannabinoids have to go through the liver before entering the bloodstream. That’s part of the reason why it takes so long for edibles and capsules to take effect.

There’s another issue, though, and it has to do with how cannabinoids are digested.

Oral Absorption Rates are Low


When cannabis is eaten or swallowed, not all of the cannabinoids make it into the bloodstream. The digestive process breaks cannabinoids down, resulting in a much lower absorption rate. The absorption rate for CBD taken orally is somewhere between 13 and 19 percent.


That means for every 30 mg of CBD taken, only about 4 to 6 mg make it into the bloodstream. The majority of it is broken down and removed from the body. So, how can you increase the absorption rate of CBD?

With certain foods and consumption methods.

You May Also Like