Oral Semaglutide Heart Benefits

Semaglutide is well-known for its ability to treat both type 2 diabetes and obesity. But it’s quickly gaining attention for something else—its potential heart health benefits.

While most studies have focused on injectable semaglutide, which has shown promising results in reducing the risk of heart issues, researchers are now looking at whether the oral version of the medication can offer the same benefits.

Oral Semaglutide and Heart Health

Obesity is a major risk factor for heart disease. Semaglutide, primarily known for its weight loss benefits, plays a crucial role in tackling obesity. By helping people lose weight, semaglutide not only improves body composition but also addresses several cardiovascular risk factors.

Research has shown that even a 5% weight loss can show clinically significant lower risk for diabetes and cardiovascular disease.

But the benefits of semaglutide may go beyond just weight loss. Recent studies have shown that semaglutide, particularly in its injectable form, can have direct positive effects on heart health.

Can Semaglutide Cause Heart Problems?

There is no evidence to suggest that semaglutide negatively impacts heart health. In fact, it is often seen as beneficial for cardiovascular health. However, there are two potential cardiovascular side effects that some users may experience: increased heart rate and heart palpitations.

Semaglutide and Heart Rate

There is a chance that semaglutide may increase your resting heart rate. While this isn’t common, some people may experience a slight rise in heart rate when taking the medication. This effect is generally mild and not typically a cause for concern in most individuals.

However, if you notice any unusual or significant changes in your heart rate, it’s important to consult your healthcare provider. They can help monitor your heart health and determine if any adjustments to your treatment are needed.

Semaglutide and Heart Palpitations

Some individuals on semaglutide may report experiencing heart palpitations, which is a feeling of a fast, fluttering, or irregular heartbeat. This is not considered a side effect of semaglutide, though. It is, however, a side effect of dehydration.

Individuals experiencing gastrointestinal symptoms often experience dehydration if they are not drinking enough fluids. If you experience palpitations, it’s important to stay hydrated and consult with your healthcare provider to rule out any other potential causes and ensure you’re managing your health effectively.

Semaglutide for Heart Disease

Semaglutide has recently gained attention for its potential to improve heart health, particularly in individuals with obesity or overweight. A recent meta-analysis published in the International Journal of Obesity, found that semaglutide use was associated with:

A 17% reduction in deaths related to cardiovascular disease
A 76% reduction in hospitalizations for heart failure
A 24% reduction in non-fatal heart attacks (myocardial infarction)
A 24% reduction in the need for coronary revascularization (procedures to restore blood flow to the heart)
A 35% reduction in strokes in people with diabetes
A 21% reduction in deaths from any cause

Many of these studies have focused on injectable forms of semaglutide and Wegovy has recently gained FDA-approval as a treatment to reduce risk of serious heart problems specifically in adults with obesity or overweight.

There are some recent studies conducted specifically to study the impact of oral semaglutide for heart disease.

SOUL study

The SOUL study, a late-stage clinical trial, tested oral semaglutide (Rybelsus) in patients with Type 2 diabetes and established cardiovascular disease (CVD), with or without chronic kidney disease (CKD).

The study showed promising results, with Rybelsus reducing the risk of a group of cardiovascular events by 14% compared to a placebo.

Results were so promising that Novo Nordisk, the manufacturer of Rybelsus, is seeking similar approvals as Wegovy.

PIONEER 6 trial

The PIONEER 6 trial was another study that evaluated the cardiovascular outcomes of once-daily oral semaglutide in patients at high cardiovascular risk. Participants were over 50 years old with established cardiovascular disease (CVD) or chronic kidney disease (CKD), or over 60 years with cardiovascular risk factors. Most patients had lived with diabetes for many years, and many had both CVD and CKD.

The results showed that oral semaglutide reduced the risk of cardiovascular events by 21% compared to a placebo. Notably, the semaglutide group experienced:

Fewer deaths from cardiovascular causes
Lower overall mortality rate

However, there were more cases of nonfatal heart attacks in the semaglutide group. Beyond heart health, oral semaglutide also demonstrated other health benefits:

Better blood sugar control,
More significant weight loss
Greater reduction in systolic blood pressure,
Modest improvements in cholesterol and triglyceride levels

How to Maximize Oral Semaglutide Heart Health Benefits

While oral semaglutide can significantly improve heart health and help manage conditions like Type 2 diabetes, incorporating certain lifestyle changes can further enhance its cardiovascular benefits. Here are some key areas to focus on:

Exercise Regularly

Adding physical activity, such as regular exercise or sports, can have a profound impact on heart health. Aim for at least 150 minutes of moderate aerobic exercise each week, along with strength training exercises.

Exercise helps lower blood pressure, improve cholesterol levels, control blood sugar, and reduce overall cardiovascular risk.

Follow a Heart-Healthy Diet

A balanced, heart-healthy diet rich in fruits, vegetables, lean proteins, and whole grains can complement the benefits of oral semaglutide. Foods high in fiber, healthy fats (like those found in olive oil, nuts, and fatty fish), and antioxidants can help reduce inflammation, lower cholesterol, and support overall heart function.

Reducing processed foods, salt, and unhealthy fats is also important for managing blood pressure and cholesterol.

Manage Stress

Chronic stress can negatively impact heart health by increasing blood pressure and inflammation (thanks cortisol). Finding healthy ways to manage stress, such as through mindfulness practices, meditation, yoga, or simply taking time to relax, can significantly benefit both your mental and physical health.

Work Closely with Your Healthcare Provider

Your healthcare provider plays a vital role in maximizing the heart health benefits of oral semaglutide. They can help monitor your progress, adjust your dosage, and provide personalized advice on managing side effects.

Always consult your healthcare provider before making any significant changes to your diet, exercise routine, or lifestyle to ensure that your plan is safe and effective for your specific needs.

Start Oral Semaglutide for Heart Health

Oral semaglutide offers a powerful combination of benefits for those looking to improve their overall health. Not only does it help manage blood sugar levels, but it can help with weight loss and heart health.

If you’re considering oral semaglutide as part of your treatment plan, it’s important to work closely with a healthcare provider. They can tailor the approach to your specific needs.

Don’t wait to take control of your health—schedule a consultation through Heally today to start your journey toward improved blood sugar management, weight loss, and heart health. Your future self will thank you.