Microdosing is a term typically associated with psychedelics. But, in recent months, a new trend has emerged that applies this concept to an entirely different category—weight loss medications.
Thanks to the influence of social media and online health communities (including licensed physicians), GLP-1 microdosing has gained significant attention for its potential to deliver weight loss benefits at lower doses.
While much of this interest stems from anecdotal evidence and influencer-driven trends, some studies have begun exploring whether microdosing GLP-1 medications can offer a viable alternative to full-dose treatments.
What is microdosing GLP-1?
Microdosing GLP-1 (glucagon-like peptide-1) receptor agonists refers to the practice of taking smaller doses of these medications. This can be done one of two ways:
- Gradually increasing the dosage over time to identify the lowest effective dose for weight loss
- Gradually decreasing the dosage over time to find the best maintenance dose for weight loss or to stop the medication completely
It’s important to note that microdosing GLP-1 is not currently an approved medical practice. The standard doses and the standard dosing schedule is still the recommended path.
Your dosing and schedule should only be decided under the guidance and supervision of a healthcare professional. Those contemplating microdosing should avoid this practice unless specifically directed by their doctor.
Why are people microdosing GLP-1 weight loss medications?
There are several reasons individuals are considering microdosing GLP-1 weight loss medications:
- Side Effects. Microdosing can help minimize common side effects associated with these medications, such as nausea or gastrointestinal discomfort, by allowing the body to adjust even more gradually to the drug.
- Cost. For many, the expense of full-dose medications can be a significant barrier. Microdosing may enable individuals to manage their costs while still benefiting from the weight-loss effects.
- Maintenance. Once individuals have reached their goal weight and are not maintaining the loss, they may not want to continue taking full doses of the medication. Dr. Brett Osborn, a neurosurgeon and expert in longevity, believes that microdosing is crucial for individuals who have successfully lost weight on standard doses to maintain their weight loss.
- Slower Weight Loss. Many people prefer a slower, more gradual approach to weight loss. This can also help to minimize some of the potential side effects like “Ozempic face” or Telogen effluvium (TE) (non scarring hair loss). It also theoretically helps with maintaining muscle mass.
- More Effective Transition. Individuals looking to wean themselves off GLP-1 medications may consider microdosing as a way to taper down safely while minimizing rebound.
Effectively microdosing GLP-1 weight loss medications
While there is a variety of GLP-1 medications available on the market, only a select few have been approved for weight loss. Understanding which of these medications are suitable for microdosing is important for those looking to try this approach.
What are the GLP-1 medications for weight loss?
The weight loss medications that have gained FDA-approval for weight loss are:
- Semaglutide (Ozempic and Wegovy). FDA-approved for weight loss under Wegovy.
- Liraglutide (Victoza and Saxenda). FDA-approved for weight loss under Saxenda.
- Tirzepatide (Mounjaro and Zepbound. FDA-approved for weight loss under Zepbound.
When it comes to microdosing, studies have only been done on semaglutide (Ozempic and Wegovy).
Compounded semaglutide, and compounded tirzepatide offer easy ways to microdose because you can control dosing.
GLP-1 microdosing with Semaglutide (Ozempic and Wegovy)
Recent research presented at the European Congress on Obesity (ECO) in Venice, Italy, highlights the advantages of personalized dosing of semaglutide for patients in weight loss programs.
Conducted by researchers at Embla, the study examined the effects of microdosing for weight loss and explored the benefits of tapering off the medication once participants reached their target weight.
It found that lower doses could be just as effective as the standard doses.
Microdosing GLP-1 for weight loss
During the study, patients were given the lowest effective dose—the lowest dose that showed significant weight loss. And, dosages were only increased if the patient had stopped making progress. The average dose administered was .77 mg.
The study showed an average weight loss of:
- 14.8% at week 64
- 14.9% at week 76
This is compared to the average 15-20% weight loss on the standard doses.
Microdosing GLP-1 to taper off medication
The study found that slowly reducing the medication while focusing on lifestyle changes (like diet and exercise) could help prevent rebound weight gain. Patients were tapered off over nine weeks while receiving coaching on diet and exercise.
Patients continued to lose weight during the tapering off period (average 2.1%) and were able to maintain their weight loss for the first 26 weeks.
Discuss GLP-1 microdosing with your healthcare provider
Studies suggest that microdosing GLP-1 medications can be as effective as standard doses when administered under the guidance of a healthcare professional. The optimal dose varies from person to person, so it will require a personalized plan.
Whether you’re interested in microdosing or just looking to get started with weight loss medications, Heally can help connect you to the doctor you need. Our partners can help you discuss your options and create a personalized plan, all from the comfort of your home. Register today!
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